The change of coagulation profile in two-staged arthroplasty for periprosthetic joint infection patients: a retrospective cohort study

Abstract Aims Periprosthetic joint infection (PJI) is a serious complication of total arthroplasty. We performed retrospective cohort study to evaluate (1) the change coagulation profile in two-staged arthroplasty patients and (2) relationship between outcomes reimplantation. Method Between January 2011 December 2018, 202 PJI who were operated on with included this initially. This continued for 2 years corresponding medical records scrutinized establish diagnosis based 2014 MSIS criteria. The was recorded at two designed points, preresection preimplantation. difference preimplantation evaluated. Receiver operating characteristic curves (ROC) used diagnostic efficiency predicting persistent before Results levels APTT, INR, platelet count, PT, TT, plasma fibrinogen spacer implantation significantly higher than No significant detected D-dimer, ACT, AT3 groups. AUC combined reimplantation 0.667 (95% CI 0.511, 0.823) 0.526, 0.808), respectively. Conclusion different from markers may play role eradication when two-stage performed. Level evidence III, study.